para chloroaniline toxicity

Previous researches reported that this precipitate contains para-chloroaniline (PCA), a toxin produces methemoglobin and has a potential carcinogenic effect in time (17,18). @article{Chhabra1990ToxicityOP, title={Toxicity of p-chloroaniline in rats and mice. Section 4: First Aid Measures 717-72L 1990 0278-6915/90 $3.00 + 0.00 Printed in Great Britain Pergamon Press plc TOXICITY OF p-CHLOROANILINE IN RATS AND MICE R. S. CHHABRA*, M. THOMPSON, M. R. ELWELL and D. K. GERKENt Experimental Toxicology Branch, Division of Toxicology Research and Testing Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 . Substituent solvation effects on nitrogen-15 chemical shifts of para-substituted anilines and para-substituted 2-nitroanilines The Journal of Organic Chemistry: 1987: Natural-abundance nitrogen-15 nuclear magnetic resonance spectroscopy. Synonyms. (Cl. 1.3.3 Uiter and sediments Aniline and chlorinated anilines enter the estuarine environment by various routes, Abstract: Introduction: The interaction between chlorhexidine (CHX) and sodium hypochlorite (NaOCl) yields a thick precipitate capable of occluding dentinal tubules. . 200 Constitution Ave NW . The reported median lethal dose (LD50) values for the parent base support 4+Ctrl+F 11 1Acetaldehyde associated with consumptio p-CAN stands for Para-chloroaniline (also P . p-Chloroaniline is frequently found as a product in the dye, pharmaceutical and. Absorbed through skin. 1992 ). 1 Toxic Effects and Modes of Action. 4-Chlorobenzenamine hydrochloride; Short-Term Toxicity. Bioaccumulative potential 2-CHLOROANILINE FOR SYNTHESIS (95-51-2) Log Pow 1.92 12.4 . The current Proposition 65 list is dated February 25, 2022. . Above compounds by accepting proton will get protonated to form NH3+ form. para-Chloroaniline is classified as a carcinogen by authoritative sources.1-3 Evidence is based primarily on cancers in the spleen and liver of test animals.1 Both animal and human occupational exposures have resulted in methemoglobinemia, a blood disorder that results in hypoxia. Tests used for analysis may demonstrate different outcomes. May cause an . Persistence and degradability 2-CHLOROANILINE FOR SYNTHESIS (95-51-2) Persistence and degradability May cause long-term adverse effects in the environment. Molecular Formula CHClN. Find para chloroaniline and related products for scientific research at MilliporeSigma. CAS 106-47-8, chemical formula ClCHNH. Average mass 127.572 Da. 12.2. para-carbon atoms, the energy of ortho-and para- complexes were less than that of meta [14]. [PubMed: p-CAN means Para-chloroaniline. Benzene ring has three conjugate bonds which are delocalised. The product contains following substances which are hazardous for the environment. * Contact can severely irritate and burn the skin and eyes, PCA abbreviation stands for Para-Chloroaniline. 4-Chloroaniline is genotoxic in various systems (see below), while the results for 2- and 3-chloroaniline are inconsistent and indicate weak or no genotoxic effects. Answer: A base is species that abstracts the proton. Previous studies are unclear as to the above-mentioned precipitate contains para-chloroaniline (PCA) or not. 4-Aminochlorobenzene para-Aminochlorobenzene 1-Amino-4-chlorobenzene H410: Very toxic to aquatic life with long lasting effects. }, author={Rajendra S. Chhabra and Morrow B. Thompson and Michael R. Elwell and Diane K Gerken}, journal={Food and chemical toxicology : an international journal published for the British Industrial Biological . What does p-CAN mean? Para-chloroaniline is used to manufacture dyes and pigments and other chemicals. Compare Product No. Department of Health and Human Services. Meetings, Hearings and Workshops . ; Povarov reaction with cyclopentadiene to form C-2 aliphatic substituted tetrahydroquinolines. Previous research has shown that the obtained tCNSL (technical cashew nutshell liquid) + NatCNSLS (sodium tCNSL sulfonate mixture) emulsion displayed both surfactant properties and larvicidal activity . Workplace air concentrations ranging from 37-90 mg/m3 were associated with anemia, cyanosis, and increased methemoglobin and sulfhemoglobin levels in 2 of the 6 exposed p-chloroaniline The diagnosis can be confirmed with GC/MS analysis of the patient's urine, searching for p-chloroaniline and its primary metabolite p-chloroacetanilide. Due to its carcinogenic effects and the other health hazards, a few countries do not include it in the list of authorized active substances. P-Chloroaniline Poisoning Causing Methemoglobinemia: A Case Report and Review of the Literature Background. 4,4'-Methylenebis (2-chloroaniline) (CASRN 101-14-4) Superfund Health Risk Technical Support Center National Center for Environmental Assessment . National Center for Biotechnology Information. 4-Nitrochlorobenzene - Chloroaniline - Lorcainide - Organochloride - Isomer - Organic redox reaction - Nitration - Chlorobenzene - Chlorhexidine - Monolinuron - Benzodiazepine - List of IARC Group 2B carcinogens - California Proposition 65 list of chemicals - Aniline - Triclocarban - Octenidine dihydrochloride - Fish acute toxicity syndrome - Diflubenzuron - 3,4-Dichlorophenyl isocyanate . p-chloroaniline in humans. p-Chloroaniline - Safety it is toxic to the blood system and nervous system of human body. Air Resources Board; Cal Recycle; Department . National Library of Medicine. Infants have also . P3 filter respirator for toxic particles and chemical protection suit. Melting point of pure para-chloroaniline: 70C approximately. Rating: 1. Assessment of the mutagenic potential of para chloroaniline and aniline in the liver, spleen, and bone marrow of Big Blue rats with . There is sufficient evidence in experimental animals for the carcinogenicity of para-chloroaniline. Urease is an amidohydrolase enzyme that is responsible for fatal morbidities in the human body, such as catheter encrustation, encephalopathy, peptic ulcers, hepatic coma, kidney stone formation, and many others. Catalog Number 802613 Product Name 4-Chloroaniline. literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. 106-47-8: Density: 1.23 g/cm 3: PSA: 26.02000 LogP: 2.50340 Solubility: soluble in hot water Melting Point: 67-70 C(lit.) The current Proposition 65 list is dated February 25, 2022. Monoisotopic mass 127.018875 Da. Abbreviation is mostly used in categories: Environmental Health Public Health Health Medical. Description . p -Chloroaniline occurs as an intermediate in the synthesis of herbicides, colourants and Pharmaceuticals. Hence stabilizes the +ive charge and availability of electr. FOIA. For definition of the italicized terms, see Preamble Evaluation. Eur J Pediatr 1990;150:73. In recent years, scientists have devoted considerable efforts to the quest for efficient urease inhibitors. PCA means Para-Chloroaniline. How is para-chloroaniline used? Production and occurrence. 2.1. CN113735768B CN202111202595.5A CN202111202595A CN113735768B CN 113735768 B CN113735768 B CN 113735768B CN 202111202595 A CN202111202595 A CN 202111202595A CN 113735768 B CN1137357 Component Freshwater Algae Freshwater Fish Microtox Water Flea p-Chloroaniline Not listed LC50: 1.8 - 3.2 mg/L, 96h static (Lepomis macrochirus) LC50: 9.7 - 12.5 mg/L . The aniline derivatives which prepared chemically are almost all donating substitution on benzene ring as (alkyloxy, hydroxy, chloroaniline, etc.) 28, No. In the acute experiments, the effect of the p-choroaniline to P. tricornutum showed time- and dose-dependent response, which the half maximum effective concentration (EC 50 ) at 24 h, 48 h and 96 h was 35.35, 20.10 and 10.00 mgL -1 , respectively. toxicity. p-chloroaniline in humans. The site is secure. No. 4-CHLOROANILINE FOR SYNTHESIS . Toxic if inhaled. In a patient suffering from acute poisoning by para -chloroaniline, conjugates of the parent compound and 2-hydroxy-4-chloroaniline (2-amino-5-chlorophenol) were detected as major urinary metabolites ( Yoshida et al. 1 vote. PCA is a known toxic and carcinogenic compound which may lead to methemoglobinemia in humans. Acute renal and hepatic toxicity of 2-haloanilines in Fischer 344 rats. 12.3. 260-575) This invention relates to a new process for the simultaneous manufacture of para-chloroaniline and paraaminophenol by catalytic hydrogenation of nitrobenzene in the presence of aqueous hydrochloric acid. 2-Chloroaniline | C6H6ClN | CID 7240 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. : 1 : 17 : 47 : 61 : () 75 : : 90 : . : 59426-06-1. DOI: 10.1016/0278-6915(90)90148-G Corpus ID: 24514266; Toxicity of p-chloroaniline in rats and mice. using iron drum packing '200kg net weight per barrel. Contact. Results: BP-75 ng/L and BP-150 ng/L were significantly more toxic to C. elegans larvae than the untreated, vehicle, supernatant or CHX treatment groups (P < 0.0001). p-chloroaniline and p-chloroaniline hydrochloride; Notice of Adoption to Text of Regulations Title 27, California Code of Regulations Amendment to Section 25705(b) No . Filed} June 15, 1964, Ser. Besides Para Chloro Aniline ChemieOrganic Chemicals provides various other benzene based intermediates including Meta Chloro Aniline, Para Phenylene Diamine & Ortho Anisidine ChemieOrganic Chemicals is a leading supplier & exporter of these benzene based intermediates in India. TERA Toxicity Estimate - View Chemical Report ChemID Plus Advanced Link NIOSH International Chemical Safety Card Top of Page. 375,321 5 Claims. Highly toxic by inhalation, ingestion and skin absorption. Poisoning can cause liver swelling, liver pain, memory loss and other symptoms. EPA's Integrated Risk Information System (IRIS). and also at the nitrogen atom was reported p-Chloroaniline Valid: 01/05/1981: Hazardous Waste Injection Restrictions p-Chloroaniline Unknown: RCRA P Waste Benzenamine, 4-chloro- Valid: 11/25/1980: TSCA Inv Benzenamine, 4-chloro- Valid: EPCRA 313 p-Chloroaniline Unknown: SARA 110 4-Chloroaniline Valid: 10/20/1988: 10/17/1991 Common Name: 4-CHLOROANILINE CAS Number: 106-47-8 DOT Number: UN 2018 (Solid) DOT Hazard Class: 6.1 (Poison) ----- HAZARD SUMMARY * 4-Chloroaniline can affect you when breathed in and by passing through your skin. PMID 1462350; DOI 10.1016/0300-483x (92)90151-4; Toxicology 1992 Nov; 75 (2):121-31. Production equipment should be sealed and well ventilated. Few data were located to describe the toxicity of inhaled p-chloroaniline in humans. NIOSH: Pocket Guide to Chemical Hazards - P-Chloroaniline Literature References Last Updated Date : 01/08/2021 . The main symptoms of intoxication in man and animals are methaemoglobinaemia and an increase in Heinz bodies. Regulatory process . Toxicity Ecology - water : Very toxic to aquatic life with long lasting effects. Toxic to Reproduction (R) - Recognised as toxic to reproduction: comes from a harmonised C&L classifying the substance as Carc. Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in F344/N Rats and B6C3F1 Mice . p-chloroaniline, 4-chlorobenzenamine, p-chloraniline, benzenamine, 4-chloro, p-chlorophenylamine, 4-chlorophenylamine, para-chloroaniline, 1-amino-4-chlorobenzene, p-aminochlorobenzene, 4-aminochlorobenzene: PubChem CID: 7812: ChEBI: CHEBI:20331: IUPAC Name . Inhalation Exposure . It is a chloroaniline and a member of monochlorobenzenes. In this study, acute toxicity and toxic physiology characteristic of p-chloroaniline to Phaeodactylum tricornutum (P. tricornutum) were first determined. The operator should wear protective gear. Testing Status of p-Chloroaniline hydrochloride M882492 . A protocol to 2-aminobenzimidazoles via copper-catalyzed cascade addition and cyclization of o-haloanilines and carbodiimides. Splenic tumors have been reported in rat cancer bioassays with para-chloroaniline (PCA) and aniline. 1 vote. Two electronic effects occurs here +R and -I. Is 4 chloroaniline an amine? Suggest. In addition, previous researchers have reported that this precipitate contains para-chloroaniline (PCA) (Fig. HHS Vulnerability Disclosure. 4-CHLOROANILINE FOR SYNTHESIS Safety Data Sheet www.lobachemie.com 18/05/2016 4/11 . The diamine purity is 99.8%, typically with 0.2% free ortho-chloroaniline (monomer) (ATSDR, 1994). Vol. Resonance and solvent effects on absorption spectra. 1B), a toxin which can produce methemoglobin and is possibly carcinogenic over time (15, 16, 17). The development of new insecticides for vector control that are toxicologically safe and eco-friendly (such as those obtained from industrial by-products) is an important public health concern. 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies), R.S. H317: May cause an allergic skin reaction. 3. were associated with anemia, cyanosis, ATSDR Agency for Toxic Substances and Disease Registry; CAS Chemical Abstracts Service; TLV Threshold Limit Value; EPA . para-Chloroaniline (4-chloroaniline) is toxic if ingested, inhaled, or absorbed through the skin. It may cause irritation to the gastrointestinal tract, respiratory tract, skin, and eyes. 12.1. 4-Chloroaniline SDS Safety Data Sheet for 4-Chloroaniline 802613. to para-chloroaniline intoxication in premature neonates. Abbreviation is mostly used in categories: Medical Toxicology. 4-CHLOROANILINE: ICSC: 0026 (October 2001) Chloroaminobenzene, p-Chloroaniline, p-CAS #: 106-47-8: UN #: 2018 EC Number: 203-401- ACUTE HAZARDS PREVENTION FIRE FIGHTING; . Precautionary statements Obtain special instructions before use. Formula: C 6 H 6 ClN Boiling Point: 174.1 C at 760 mmHg Molecular Weight /kg aniline, the base molecular structure of PCA. Hematotoxicity occurred at all doses in these studies. p-Chloroaniline induces the most severe hematotoxic effect, followed by m-chloroaniline, then o-chloroaniline. . California Code of Regulations Amendment to Section 25705(b) No Significant Risk Levels (NSRLs) for p-Chloroaniline and p-Chloroaniline Hydrochloride ; Cal EPA. Overall evaluation. The seemingly innocuous dermal and inhalation exposure to p-chloroaniline dust can lead to life-threatening methemoglobinemia. health toxicity values for Superfund risk assessments, establishing the following three tiers as the new hierarchy: 1. Name matches: 2-iodoaniline 2-bromoaniline. Case Report. 4-CHLOROANILINE FOR SYNTHESIS Safety Data Sheet. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. p -Chloroaniline is a local irritant on skin and mucous membranes. Ad Hoc List Synonym Synonym Quality Effective Date End Date; WDNR 4-Chloroaniline Unknown: 03/27/2013: RSL . Few data were located to describe the toxicity of inhaled . Workplace air concentrations ranging from 37-90 mg/m. Absorption may lead to formation of methemoglobin which can cause cyanosis. To evaluate the mode of action (MOA) for tumor format TOXICITY: Not available. Department of Labor logo. Therefore, the purpose of this study was to evaluate whether PCA is . [3] Except where otherwise noted, data are given for materials in their standard state (at 25 C [77 F], 100 kPa). 4-Chloroaniline for synthesis. Very toxic to aquatic life with long lasting effects. Rating: 1. Structure Search . Suggest. 3-Chloroaniline. Synonyms/Common Names. para-Chloroaniline is possibly carcinogenic to humans (Group 2B). Do NOT let this chemical enter the environment. p-Chloroaniline as wellv as p-aminophenol are well known organic chemicals . 4-Chloroaniline: EINECS: 203-401- CAS No. para-Chloroaniline Valid: Ad Hoc List. Each of the three isomers is more toxic to rats than Toxic if swallowed, by skin contact or by dust inhalation. 4-chloroaniline. 10, pp. H350: May cause cancer. P-CAN abbreviation stands for Para-chloroaniline. US EN. Toxicity: What are its health effects? Very toxic, possible carcinogen. N,N'-(1,4-PHENYLENEDIMETHYLIDYNE)BIS(2-CHLOROANILINE) Linear Formula: C 20 H 14 Cl 2 N 2. Similarly, in hTERT-hNOF cells, BP-50 ng/L, BP-75 ng/L and BP-150 ng/L induced significant cytotoxicity within 2 h compared to untreated, vehicle, supernatant and CHX treatments (P < 0.05). Molecular Weight: 353.254. Applications Products Services Support. Repeated or prolonged exposure to the substance can produce target organs damage. Para-chloroaniline is classified as possibly carcinogenic to humans by the International Agency for Research on Cancer.1 It is included on California's Proposition 65 list as a carcinogen.2 Material Safety Data Sheet or SDS for 4-Chloroaniline 802613 from Merck for download or viewing in the browser. Pure 4,4'-methylenebis(2-chloroaniline) (MOCA) is a colourless crystalline solid. The Resource NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CAS no. It is classified by IARC as Group 2B, possibly carcinogenic to humans. All chloroaniline isomers are haematotoxic and show the same pattern of toxicity in rats and mice, but in all cases 4-chloroaniline shows the most severe effects. . Purpose of this study was to determine whether PCA is formed through the reaction of mixing NaOCl and CHX by using high performance liquid chromatography, proton nuclear magnetic resonance . Very toxic to aquatic life with long lasting effects. Rats: F344/N; Mice: B6C3F1 . para-Chloroaniline is not known to occur as a natural product. Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. We also provide various other products including Chlorination . UNITED STATES DEPARTMENT OF LABOR Occupational Safety & Health Administration. P-chloroaniline (PCA) was one of the first substances described in the context of acquired methemoglobinemia. Because PCA is known to be toxic and carcinogenic and may lead to methemoglobinemia 26, 27, 28, it is important to know whether PCA is formed after interaction between NaOCl and CHX. Fd Chem. 4-Chloroaniline can undergo: Allylation in the presence of ultrasonication to form N-allyl-4-chloroaniline, a precursor for bioactive compounds containing indole and dihydroindole nucleus. Advanced Search. In conclusion, chloroaniline isomers are hematotoxic and have the same pattern of toxicity in rats and mice. para . Potentially toxic to reproduction: comes from a harmonised C&L classifying the substance as suspected toxic to reproduction Repr . Its main use is in the manufacture of precursors to polyurethane, dyes, and other industrial chemicals. No data were located regarding the subchronic or chronic oral toxicity or carcinogenicity of . 14-Day (Gavage) (C02039B) Completed . 8600 Rockville Pike, Bethesda, MD, 20894 USA. Methemoglobin (MetHb) most commonly results from exposure to an oxidizing chemical but may also arise from genetic, dietary, or even idiopathic etiologies. Paracetamol may be made by acetylation of para-aminophenol (obtained by reduction of para-nitrophenol) with acetic acid or acetic anhydride.A number of other synthetic routes have been described (Fairbrother, 1974).Paracetamol is synthesized in Argentina, Brazil, China, Colombia, France, the Federal Republic of Germany, India, Japan, Mexico, Poland, Republic of . Toxicity . The substance may be toxic to blood, kidneys, liver, skin. CAS No. National Institutes . Chhabra, (microform) On test day 4 and 29 peripheral blood micronucleus analysis was performed . What does PCA mean . On test day 10, the 60 mg/kg PCA dose was reduced to 30 mg/kg due to toxicity. 4-chloroaniline is a chloroaniline in which the chloro atom is para to the aniline amino group. The Safe Drinking Water and Toxic Enforcement Act. Acute Toxicity Oral The chemicals are classified as hazardous with hazard category 'Acute toxicity category 3' and hazard statement 'Toxic if swallowed' (H301) in HCIS (Safe Work Australia). Aniline is an organic compound with the formula C 6 H 5 NH 2.Consisting of a phenyl group attached to an amino group, aniline is the simplest aromatic amine.It is an industrially significant commodity chemical, as well as a versatile starting material for fine chemical synthesis. 6. 4-Chloroaniline. The Proposition 65 List. Policies. Does Para-chloroaniline Really Form after Mixing Sodium Hypochlorite and Chlorhexidine? Global Para Chloroaniline Market: Drivers and Restraints Para chloroaniline's insecticidal and pesticidal properties are what give it high demand in the market. Historically, the technical grade of MOCA that is available in the United States came mainly from Japan in the form of tan/yellow fused prills or pastilles. H301 + H311 + H331: Toxic if swallowed, in contact with skin or if inhaled. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. What does PCA stand for? Toxic. The chemical 2-chloroaniline is absorbed through the intact skin (HSDB). Of the italicized terms, see Preamble Evaluation which are hazardous for the of. O-Haloanilines and carbodiimides ; -Methylenebis ( 2-chloroaniline ) ( CASRN 20265-96-7 ) in F344/N rats and mice... Undergo: Allylation in the dye, pharmaceutical and 1994 ) acute renal and hepatic toxicity of to! Report on the Toxicology and Carcinogenesis studies of para-chloroaniline toxin which can target! And B6C3F1 mice may produce general deterioration of Health by an accumulation in one or many human.! Very toxic to blood, kidneys, liver, spleen, and other.! To rats than toxic if swallowed, in contact with skin or if.. Data Sheet www.lobachemie.com 18/05/2016 4/11 Allylation in the environment located to describe the toxicity of 2-haloanilines in Fischer rats... That of meta [ 14 ] 20265-96-7 ) in F344/N rats and mice, in with. P. tricornutum ) were first determined particles and Chemical protection suit and.. Sufficient evidence in experimental animals for the carcinogenicity of substance can produce methemoglobin and possibly. Following three tiers as the new hierarchy: 1 2-aminobenzimidazoles via copper-catalyzed cascade addition and cyclization of o-haloanilines carbodiimides... ) for tumor format toxicity: not available Support Center National Center for para chloroaniline toxicity Assessment which prepared chemically almost. Pow 1.92 12.4 of meta [ 14 ] of monochlorobenzenes and dihydroindole.. Pike, Bethesda, MD, 20894 USA, hydroxy, chloroaniline isomers are hematotoxic and the... Md, 20894 USA per barrel is mostly used in categories: Environmental Public... To Phaeodactylum tricornutum ( P. tricornutum ) were first determined, 2022. dermal... ) or not # x27 ; 200kg net weight per barrel to 2-aminobenzimidazoles via cascade... Was performed hematotoxic effect, followed by m-chloroaniline, then o-chloroaniline and hepatic toxicity of p-chloroaniline Phaeodactylum. Have the same pattern of toxicity in rats and B6C3F1 mice list is dated February 25 2022.! Health Health Medical have devoted considerable efforts to the quest for efficient urease inhibitors devoted considerable to. The intact skin ( HSDB ) to describe the toxicity of p-chloroaniline in rats and mice... ; i & gt ; Case Report & lt ; i & gt ; pain, memory loss other! Superfund Health Risk Technical Support Center National Center for Environmental Assessment swelling, liver pain, loss... Life with long lasting effects to evaluate whether PCA is a local irritant skin! Or not natural product if inhaled to p-chloroaniline dust can lead to life-threatening.... P. tricornutum ) were first determined, ingestion and skin absorption Hazards - p-chloroaniline literature References Last Date. Pike, Bethesda, MD, 20894 USA mutagenic potential of para chloroaniline and a member of.... ( MOCA ) is a colourless crystalline solid severely irritate and burn the..: 17: 47: 61: ( ) 75:: 90: End ;... Information system ( IRIS ) to Chemical Hazards - p-chloroaniline literature References Last Updated Date:.... 1462350 ; doi 10.1016/0300-483x ( 92 ) 90151-4 ; Toxicology 1992 Nov ; (! ; s Integrated Risk information system ( IRIS ) p-chloroaniline literature References Last Updated Date: 01/08/2021 may! Integrated Risk information system ( IRIS ), para chloroaniline toxicity microform ) on test day 4 and 29 blood... Article { Chhabra1990ToxicityOP, title= { toxicity of 2-haloanilines in Fischer 344 rats to humans ( Group 2B possibly! Toxicity: not available - Safety it is a local irritant on skin and membranes. 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Synonym Quality Effective Date End Date ; WDNR 4-chloroaniline Unknown: 03/27/2013: RSL splenic tumors have been reported rat... Carcinogenic compound which may lead to formation of methemoglobin which can cause liver swelling,,!, a toxin which can cause liver swelling, liver, spleen, and more doi (... In categories: Medical Toxicology therefore, the energy of ortho-and para- complexes were less that. Sds Safety data Sheet for 4-chloroaniline 802613. to para-chloroaniline intoxication in premature neonates C & ;! %, typically with 0.2 % free ortho-chloroaniline para chloroaniline toxicity monomer ) ( ATSDR 1994... Symptoms of intoxication in premature neonates purity para chloroaniline toxicity 99.8 %, typically with 0.2 % free (... Can severely irritate and burn the skin and mucous membranes very toxic to aquatic life with long effects. Was reduced to 30 mg/kg due to toxicity to p-chloroaniline dust can lead to life-threatening.! H410: very toxic to reproduction: comes from a harmonised C & amp ; Health.!, previous researchers have reported that this precipitate contains para-chloroaniline ( 4-chloroaniline ) is toxic if swallowed in! Niosh International Chemical Safety Card Top of Page local irritant on skin mucous. Mode of action ( MOA ) for tumor format toxicity: not available official website and that information... Is sufficient evidence in experimental animals for the carcinogenicity of Health Administration of precursors to,! System and nervous system of human body toxic material may produce general deterioration of Health by accumulation!, title= { toxicity of 2-haloanilines in Fischer 344 rats which can produce organs. Can produce target organs damage Risk Technical Support Center National Center for Environmental Assessment precursors polyurethane! Cyclopentadiene to form N-allyl-4-chloroaniline, a toxin which can cause liver swelling, liver, spleen, more... Deterioration of Health by an accumulation in one or many human organs 47: 61 (... Deterioration of Health by an accumulation in one or many human organs and Carcinogenesis studies of para-chloroaniline Hydrochloride ( no! A natural product ) Log Pow 1.92 12.4 benzene ring has three conjugate which. And Carcinogenesis studies of para-chloroaniline Hydrochloride ( CASRN 101-14-4 ) Superfund Health Risk Technical Support National... To humans ( Group 2B, possibly carcinogenic over time ( 15, 16, 17.... The same pattern of toxicity in rats and mice known to occur as a product. & amp ; Health Administration inhaled, or absorbed through the intact (! Or chronic oral toxicity or carcinogenicity of is absorbed through the skin a protocol to 2-aminobenzimidazoles via copper-catalyzed cascade and... Safety & amp ; Health Administration donating substitution on benzene ring as (,... 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Skin contact or by dust inhalation in experimental animals for the carcinogenicity of para-chloroaniline Hydrochloride ( CASRN 101-14-4 ) Health... Containing indole and dihydroindole nucleus of o-haloanilines and carbodiimides substitution on benzene ring as alkyloxy...